Particularities of Different Types of Leukemia

Leukemia is a form of cancer that occurs at the level of the spinal marrow. Inside the spinal marrow there is a type of immature blood cells that are called stem cells. These cells have a neutral initial state and later develop into different types of blood cells (white blood cells, red blood cells and platelets). Leukemia interferes in the normal process of cell maturation, leading to an accumulation of partially developed blood cells in the marrow, blood and later in body organs. Most of these resulted cells are inefficient inside the organism, as they can’t carry out the activity of normal blood cells.

Depending on to the rate of development, the disease can either be acute leukemia (developing very rapidly), or chronic leukemia (slow developing).

Particular to acute leukemia is the inability of stem cells (immature cells that can be found within the bone marrow) to reach the state of maturity. These immature blood cells tend to continuously divide and they accumulate in the bloodstream. Acute leukemia develops very rapidly and people who suffer from it need immediate treatment and specific therapy. If mistreated or ignored, acute leukemia causes the death of affected patients within a few months. While certain forms of acute leukemia are usually successfully treated, other forms don’t respond well to the specific treatment.

A characteristic of the chronic type of leukemia is that the diseased cells usually come from more mature cells, but in most cases they aren’t developed normally. The leukemia cells have long periods of life and they tend to accumulate within the bloodstream. Although normal people have between 5000 and 10000 white blood cells in their body, people who suffer from chronic leukemia may have more than 100000.

Lymphocytic and myelogenous types of leukemia are developed from different types of cells: the lymphocytic type of leukemia develops from cells called lymphoblasts or lymphocytes in the spongious tissue of the bones, while the myelogenous type of leukemia (sometimes refered to as myeloid and myelocytic leukemia) develops from myeloid cells. Judging by the types of cells involved in the development of leukemia and by the rate of cellular division specific to each form of the disease, the main types of leukemia are: acute myelogenous leukemia (AML), chronic myelogenous leukemia (CML), acute lymphocytic leukemia (ALL) and chronic lymphocytic leukemia (CLL).

In addition to the common forms of chronic leukemia, there are also some rare types. Hairy cell leukemia (HCL), just like chronic lymphocytic leukemia, has a slow progression. The cells of hairy cell leukemia are different from other diseased cells mainly through their aspect. Hairy cell leukemia doesn’t usually respond well to treatment. Prolymphocytic leukemia is a very rare and unusual form of chronic lymphocytic leukemia.

Some cancers, called lymphomas, are caused by abnormal blood cells that are present in the lymph nodes, liver, spleen or other organs. These particular types of cancer don’t occur at the levels of the bone marrow and have a development that is not characteristic to most forms of lymphocytic leukemia.

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Survival Rates of Patients with Leukemia

Although medical science has evolved significantly in the last decades, the treatment of leukemia is still a major issue in present. Modern medicine doesn’t hold the cure for leukemia and medical treatments available these days provide differentiated results. Survival rates depend on the promptitude of diagnosis, the type of treatment and the patients’ responsiveness to specific cancer therapies and treatments. Although leukemia can’t always be completely overcome, the progression of the disease can be slowed down and its malignant effects can be contained with the help of existent cancer treatments. Thus, the life expectancy of patients with leukemia has risen considerably in the last three decades. By contrast, the mortality rate registered among patients with leukemia has known a pronounced decrease in the last decade.

The treatment of leukemia is focused towards achieving a complete remission with minimal side-effects. Complete remission refers to absence of leukemia traces at cellular level. Patients who present no evidence of malignant cellular activity after completing the treatment of leukemia are considered to be completely cured. By contrast, relapse indicates a recurrence of leukemia specific symptoms and physiological signs.

In the case of patients with acute leukemia, a remission that lasts for more than five years after the treatment suggests a complete recovery. This five-year period is considered to be critical for leukemia sufferers, as it can make the difference between relapse and complete recovery.

In the last few decades, the five-year survival period of patients with leukemia has tripled. While in the 60’s the five-year survival rate was around 15 percent, nowadays it revolves around 50 percent. This five-year survival period is strongly influenced by patients’ age and the type of leukemia. Statistics indicate that the five-year survival rate for patients with acute lymphocytic leukemia (ALL) is around 60 percent, while the five-year survival rate for patients with chronic lymphocytic leukemia (CLL) is higher, reaching the value of 70 percent. By contrast, the prognosis of patients with myelogenous leukemia is less favorable. The same five-year survival rate for patients diagnosed with acute myelogenous leukemia (AML) is around 14 percent, while an estimated 32 percent of patients with chronic myelogenous leukemia (CML) exceed this five-year survival period.

The five-year survival rate for children diagnosed with acute lymphocytic leukemia revolves around the value of 80 percent, while the overall survival rate of children with acute lymphocytic leukemia is less than 45 percent. This type of leukemia is the most common form of cancer diagnosed in children. Due to the fact that it predominantly affects young patients with ages between 3 and 15, the disease is referred to as childhood leukemia.

In the United States, the mortality rate for children with leukemia has decreased with 60 percent in the last three decades. In spite of this fact, leukemia is still the leading cause of death among young patients with ages under 15.

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Promyelocytic Leukemia

Promyelocytic Leukemia a growth of the bone marrow in which there is a deficit of mature blood cells in the myeloid line of cells and a surplus of immature cells called promyelocytes. Promyelocytic leukemia is due to a translocation between chromosomes 15 and 17 which is symbolized t(15;17). This translocation is not a mere indicator of promyelocytic leukemia but the main cause. Promyelocytic leukemia generally comes under the acute form leukemia. It is also termed as acute promyelocytic leukemia (APL).
In 1957, promyelocytic leukemia was first accepted as an individual disease entity. It accounts for 5-10% of cases of acute myeloid leukemia (AML). The peak incidence of promyelocytic leukemia is amongst young adults. Promyelocytic leukemia is thought of as a type of AML and is classified as the M3 variant of AML.
Symptoms of promyelocytic leukemia are generally nonspecific and comprise of fatigue, minor infections, or hemorrhagic diathesis. There is usually pancytopenia with anemia, low levels of the granulocytes and monocytes, and low levels of platelets. Transfusion is thus an alternative that can be availed of.
Treatment of promyelocytic leukemia is different from that for all other forms of AML. Majority patients are now treated with all-trans-retinoic acid (ATRA). ATRA is a form of "differentiation therapy." It activates the retinoid receptor RAR and causes the promyeloctes to mature and this deters them from proliferating.
Even though ATRA cannot eliminate the leukemic clone it can stimulate a complete diminution in most patients suffering from promyelocytic leukemia by causing the promyelocytic leukemia -blasts to mature. ATRA is therefore used in combination with chemotherapy including an anthracycline drug.
Chances of survival are better with the combination of ATRA and chemotherapy than chemotherapy alone. This is because ATRA combined with chemotherapy accounts for a slightly higher rate of complete remissions while allowing significantly fewer relapses. Maintenance cure with ATRA, and possibly with low-dose chemotherapy, further reduces the occurrence of relapse. The advent of ATRA therapy has revolutionized the treatment of promyelocytic leukemia and clearly enhanced the prognosis.
Promyelocytic leukemia is connected with a characteristic cellular picture classified as M3 in the French-American-British Classification and responds positively to treatments including retinoids, chemotherapy and, most recently, arsenicals.

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Signs-Symptoms And Life-Expectation In Acute Leukemia

First occurring signs in the development of acute forms of leukemia are bruising and bleedings caused by the decreased number of platelets, fatigue and pales due to the anemia caused by insufficient red blood cells, reoccurring infections and late healing due to abnormal number and function of white blood cells. These symptoms are however not specific for the Leukemia condition and for a precise diagnose further testing is required such as analysis of blood and bone marrow.
A certain cause of Leukemia is not yet known as it can affect persons of all ages and both sexes. A link however between leukemia and benzene prolonged exposure or high doses of radiations could be established. But most cases cannot be rationally explained.
The main target of the Leukemia treatment is to annihilate all existing abnormal cells in blood and bone marrow. A complete remission means no left trace of cancerous modifications. Some of the treated cases show a reoccurrence of the disease with other signs and symptoms. In acute leukemia forms, after five years of remission after treatment the patient can be qualified as cured and the condition rarely reoccurs.
In the last 25 years the percent of surviving subjects has increased due to new therapy ways. The overall five-year survival rate is 44% today, with significant progresses compared to the 1960’s rate of only 14%. The rate of survival differs by age, type of leukemia and previous health status. In the case of acute lymphocytic Leukemia the rate is 58%, in the chronic form it reaches 71%, in acute myelogenous Leukemia the rate is 14% and the chronic form reaches 32% five-year survival.
In present there are about 144000 patients suffering from Leukemia in the USA. The rate of survival in children suffering from acute lymphocytic leukemia is 81% if detected in early stage. For children diagnosed with acute myelogenic Leukemia the rate is 43%.
In 2001 about 12500 male subjects are known to have died from Leukemia and a lower number of 9500 women, in the United States. The estimated number of chronic lymphocytic deaths yet to occur is 4600 and 1400 from acute lymphocytic forms. Acute myelogenous Leukemia is expected to produce 7200 deaths and chronic myelogenous Leukemia about 2300 deaths. Other forms of leukemia will be responsible for approximately 600 death cases.
For males under 40 and for women less than 20 leukemia represents the main cause of death. The estimated rate of deaths in males of Leukemia is 25% higher than in females. The percent of death cases in children has decreased in the last 30 years but the rate still remains high.
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General Aspects of Leukemia

Many people suffer from leukemia these days. A large number of cases of cancer are identified to be leukemia. Leukemia is a sort of cancer of the blood and marrow. The disease is characterized through the overproducing of immature blood cells (stem cells) that aren’t able to fully develop and to carry out the activities of normal blood cells.
According to their functions and structure, there are three different types of cells within the normal blood: red blood cells, white blood cells and platelets. Through the process of hematopoiesis, these three types of blood cells are developed from a distinctive type of blood cell called stem cell. Stem cells divide and go through several stages of development to finally form a mature blood cell of a particular type, with a certain, distinctive function in the body. The process through which a stem cell morphs into a mature blood cell takes place within the bone marrow.
According to the speed of development and the persistence of the disorder, there are two types of leukemia: acute leukemia and chronic leukemia. Acute leukemia is known to develop very rapidly, while chronic leukemia is developed slowly. According to the types of blood cells affected by the disease, leukemia can either be lymphocytic or myelogenous.
Lymphocytic and myelogenous types of leukemia are developed from different types of cells: the lymphocytic type of leukemia develops from cells called lymphoblasts or lymphocytes in the spongious tissue of the bones, while the myelogenous type of leukemia (sometimes refered to as myeloid and myelocytic leukemia) develops from myeloid cells.
In the case of acute forms of leukemia, the abnormal cells come from early, immature cells. Such forms of the disorder have a very fast rate of development, due to the fact that normal stem cells tend to multiply frequently. Leukemia cells usually don’t divide faster and more frequently than normal stem cells, they simply don’t stop their process of division when they should. Sometimes the numbers of white blood cells are very high, while in other cases they can be normal or low.
Chronic leukemia, apart from its slow development, is different from acute leukemia by the level of maturation that the diseased cells are able to reach. Stem cells affected by chronic leukemia reach a higher level of maturation but they present abnormalities and they can’t act as healthy white blood cells do. Unlike acute leukemia, in the chronic form of the disease the unhealthy cells have much longer periods of life and they tend to accumulate in different parts of the body.
Leukemia affects people of all age groups. While children usually respond better to the treatment for leukemia and sometimes deal well with the disease, adults difficultly cope with this form of cancer.
Regardless of age and sex, many people are diagnosed with forms of leukemia. Children tend to respond better to some types of leukemia, while adults difficultly cope with the disease. The cases of acute leukemia exceed those of chronic leukemia by approximately 10 percent. Older adults seem to be affected the most by acute leukemia. Around two thirds of acute leukemia cases seem to occur after the age of 60.
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Interesting Facts About Acute Leukemia

Leukemia is also known as blood cancer. However, this term is a misnomer because rather than causing cancer in the blood, the cancer is caused in the bone marrow and it affects the white blood cells. These cells are responsible for fighting infections, bacteria and viruses that enter our body. Once the white blood cells are affected, our body gets weakened and is exposed to infections.

There are several types of leukemia and the treatment varies depending on the type. However, the two main types of leukemia are acute leukemia and chronic leukemia. Chronic leukemia is considered to be milder; in other words not all the white blood cells are defective and the progress of the disease is much slower than acute leukemia.

Acute leukemia advances rapidly and all the white blood cells are not normal. However, in some cases it is easier to treat than chronic leukemia.

In the United States, each year thousands of people are diagnosed with acute leukemia. However, it has been seen that a large number of children, mostly around 4 years old, are afflicted more frequently by acute leukemia. The good news is that more and more cases are being cured and there is constant research for new medication and treatment methods.

The cause of acute leukemia is unknown. The only thing that one can say for certain is that some people are at a higher risk of getting the disease than others. People who are exposed to radiations or certain chemicals have the highest chance of contracting the disease. In addition, there is the hereditary factor. It has been seen that children receive the defective gene from their mother and this gene may lead to acute leukemia.

People who have leukemia tend to bruise easily or bleed easily from the nose and gums. In addition to weak immune system, there is a general feeling of fatigue and unexplained weight loss. The disease by itself does not have any specific symptoms.

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Possible Leukemia Causes and Risk Factors

Leukemia is a disease that is considered to be life-threatening. It requires prompt intervention when discovered, in order to maximize the chances of recovering through specific treatment and therapy. Leukemia is basically a type of cancer of the bone marrow and blood, caused by inappropriate cellular activity. The disease can be of different forms, according to the types of blood cells that cause its development. Also, if leukemia is developing rapidly, it is called acute leukemia, while if the disease is developing slowly, it is referred to as chronic leukemia.

The direct leukemia causes are still unknown. In present, medical science isn’t able to establish the specific leukemia causes. However, a strong connection between certain genetic factors and the development of the disease has been revealed. Leukemia occurs on the background of genetic failure that causes the excessive production of incomplete, partially matured blood cells. Also, leukemia has a hereditary character, allowing the transmission of genetic predispositions to disease from one generation to another. Although many factors are known to contribute to the development of leukemia, they alone can’t be considered leukemia causes.

Despite the fact that statistics indicate a higher incidence of the disease in people that are exposed to some environmental factors of risk, leukemia doesn’t seem to be caused by neither of them in particular. Among the environmental factors that are thought to be leukemia causes, here are some of the most plausible ones:

- Smoking – smoking is thought to increase the chances of being affected by leukemia. Although statistics show that around 20 percent of acute leukemia cases are related to smoking, leukemia also occurs to people that don’t smoke and therefore it can’t be considered a leukemia cause on itself;

- Prolonged exposure to radiation – Radiation is considered to facilitate the development of leukemia. It is believed that exposure to X-rays can be a leukemia cause;

- Prolonged exposure to benzene – statistics reveal that this is a major factor of risk in some forms of leukemia, such as myelogenous leukemia;

- Chemotherapy and cancer treatment – previous cancer treatments and chemotherapy are known to facilitate the occurrence and development of leukemia and can be considered plausible leukemia causes. Within a few years from the completion of chemotherapy and other treatments for certain forms of cancer, most people can develop leukemia.

Among the genetic factors that are considered to be leukemia causes, the following ones are thought to be the most important:

- chromosome abnormalities – some rare genetic syndromes are known to contribute to leukemia causes;

- Immune system genetic problems - a weak immune system is very likely to facilitate the occurrence of leukemia and therefore can be considered a leukemia cause;

- Down syndrome – children born with this syndrome have a very high risk of developing acute leukemia.

The list of possible leukemia causes can continue further, but these are the most common factors that are considered to be interrelated with leukemia. While some of them can be prevented, others reside within the genes and in present can’t be corrected. In future, however, thanks to medical advance, we will probably be able to prevent leukemia and other forms of cancer.

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How Is Leukemia Treated?

Leukemia is a type of cancer that affects the blood and bone marrow. There are two types of leukemia, chronic and acute, which are treated differently and have different symptoms. Acute leukemia rapidly progresses and needs immediate, aggressive treatment. Chronic leukemia can take months or years to show symptoms and may not need immediate treatment but will require ongoing monitoring.

Chemotherapy utilizes chemicals to treat the cancer. It causes many side effects such as hair loss, nausea and decline of the immune system. The complete course of therapy can be from two to five years including maintenance. This is the most common form of treatment for leukemia with the desired result being total remission. Even without symptoms, ongoing monitoring must occur to guard against relapse.

Radiation therapy is another form of treatment. It is painless and in low doses causes very few side effects. Where the radiation is concentrated and the exposure levels will determine the side effects, if any, and the severity of them. Damage to the skin, swelling and infertility are among the possible side effects.

A bone marrow transplant is an effective way to prolong the life of cancer patients. It is, however, a risky surgery and requires a donor which can be difficult in attaining. These surgeries should be performed at state of the art hospitals specializing in cancer treatment. This surgery has a high mortality rate and is therefore used only in life threatening cases.

Immunotherapy is a means to stimulate the immune system so the body can attack the cancer cells. This type of treatment is still in its early stages and continually under development. It is believed that this type of treatment may prove less harmful than chemotherapy or radiation therapy and may someday supplant these treatments as a method for treating cancer.

Long term effects of leukemia treatments may cause anemia. This side effect can be treated by blood transfusions or platelet transfusions. There are risks with transfusions but it is believed transfusions will help reduce the threat of additional complications such as heart attacks. Doses of antibiotics are also generally prescribed to leukemia patients to help counteract the danger of infection cause by declined immune system or treatment side effects.

There are currently almost 200,000 people in the United States diagnosed with leukemia and an estimated 35,000 new cases will be diagnosed this year. It is the leading cause of death for people under the age of 20. There are many treatment facilities throughout the United States specializing in cancer treatment. Early diagnosis, aggressive treatment, and monitoring will help prolong life and increase chances of a person going into remission.

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Leukemia Treatments

Leukemia is considered one of the most dangerous forms of cancer, given that it affects the blood and its functions. It is also considered as dangerous because of the very difficult symptoms that people who suffer from the disease exhibit, such as abnormal bleeding and increased incidence of infections. However, recent developments in medical research have now increased the chances of beating the disease.

Treatments

When a person is diagnosed with leukemia, he is most likely referred to a hematologist-oncologist, who is a doctor that specializes in the treatment of leukemia. After examination, the doctor then suggests the possible treatments that can be employed to treat the leukemia, which will depend on the type and severity of the leukemia. The usual treatment of leukemia is divided into two categories: treatments that are aimed at fighting the cancer and treatments that are aimed at relieving the symptoms and the side effects of the disease.

Among possible cancer treatments, the most commonly used to fight leukemia is chemotherapy, which involves the use of very powerful medication to kill leukemia cells. This therapy is usually done in cycles, and the medication can either be taken intravenously or orally. However, although chemotherapy is very effective in killing cancer cells, it can also kill healthy cells, which explains some of its side effects. Some of these side effects include hair loss, irritation in the esophagus, and other symptoms. In recent years, newer agents have been developed and are being used for chemotherapy; these new agents do not affect healthy cells as much as the conventional agents used in chemotherapy.

Another treatment includes the use of biological drug therapy; leukemia patients take biological drugs that act in a manner similar to the body's immune system such as antibodies. These drugs are designed to also target cancer cells.

Another form of therapy is radiation therapy, which involves the use of radiation that is targeted on the organs where large deposits of cancer cells can be found. However, this form of therapy can have some negative long-term effects.

Leukemia is one of the most dangerous types of cancer because it has the potential to spread the cancer to other organs. However, developments in medical research have now increased the chances of beating the cancer.

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Life Expectancy For Leukemia

Leukemia is cancer of the white blood cells. The bone marrow produces uncharacteristic white blood cells that do not function properly. These white blood cells eventually crowd out normal white blood cells, red blood cells, and platelets. One blood cell of a person suffering from leukemia goes awry and the body produces large numbers of this cell. In most cases the cell that goes awry is the white blood cell. There are four main types of leukemia. These vary on the type of white blood cell affected and the speed of progression. Acute lymphoblastic leukemia (ALL), acute myelogenous leukemia (AML), chronic lymphocytic leukemia (CLL) and chronic myelogenous leukemia (CML) are the four main types. Life expectancy of a patient suffering from leukemia varies from one type to another.

The medical fraternity's understanding of and ability to treat leukemia has developed considerably in recent decades. In 1960, the 5-year survival rate for all types of leukemia was about 14%. It has now increased to about 50%. Children suffering from leukemia have a higher life expectancy rate, while people over the age of sixty have a comparatively lower life expectancy rate. The two main forms in which leukemia can be broadly termed are chronic and acute. Acute leukemia means that the disease grows rapidly and the usually life expectancy without treatment varies from a few weeks to a few months. Chronic leukemia, however, progresses gradually and with the appropriate cure, life expectancy can be up to 20 years or more after the onset of sickness.

Life expectancy of patients depends on the different factors such as health, age of the patient, severity of the disease, and treatment provided. While the life expectancy amongst ALL and AML is short due to its rapidly progressing nature, life expectancy amongst CLL and CML extend from three years to twenty years.

Over the years statistics have shown that life expectancy among people suffering from leukemia has grown considerably. This increase can be attributed to advanced studies and research. Innovation and invention of new and effective treatment procedures have also contributed to such an increase.

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Treatment for Leukemia - What is Leukemia?

More and more research is being done now about leukemia and what we know about it. Scientists and researchers are learning more and more as they study its causes. They are also developing better and much more effective ways to treat it. Adults and children with leukemia can look forward to a better quality of life and less chance of dying from the disease because of all the research that has been done and continues to be done.

Leukemia is cancer that starts in the blood-forming tissue of the body, like the bone marrow. This year, it is estimated that there will be another 44,270 cases of leukemia diagnosed and about 21,700 deaths caused by it. That's too many. One is too many, but these figures are way, way down from what they were only a few years ago. There was a time when a diagnosis of leukemia was a certain death sentence; but that is no longer the case, and the numbers are improving every year.

The bone marrow in people who have the disease produces abnormal white blood cells. These abnormal cells are the leukemia cells. In the beginning, they function and behave almost normally, but eventually they start to crowd out normal white blood cells, red blood cells, and platelets. When this happens, the blood can't do its job, which is carry oxygen to all parts of the body.

There are four basic types of leukemia:

1. Chronic lymphocytic leukemia: It is responsible for about 7,000 new cases of leukemia each year. People diagnosed with the disease are usually over the age 55, and chronic lymphocytic leukemia almost never affects children.

2. Chronic myeloid leukemia: It is responsible for about 4,400 new cases each year. Adults are most often diagnosed with chronic myeloid leukemia.

3. Acute lymphocytic leukemia: It is responsible for about 3,800 new cases each year. Acute lymphocytic leukemia is the most common type of leukemia in young children, but it can also affect adults.

4. Acute myeloid leukemia: It is responsible for about 10,600 new cases each year. Acute myeloid leukemia occurs in both adults and children at about the same rate.

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